EFFICACY OF CLOSANTEL AGAINST FASCIOLA-HEPATICA IN KOREAN NATIVE GOATS

Closantel (Flukiver(TM)), a salicylanilide antiparasitic compound, was tested in Korean native goats infected with Fasciola hepatica. The go ats were administered closantel once orally at a dose of 10 mg/kg body weight. Efficacy was monitored weekly by fecal examination of all inf ected animals starting the second week post-treatment and continuing f or 3 weeks. Closantel elicited 80.3, 97.8 and 92.7% efficacy in goats with naturally-acquired fasciolosis at the second, third and fourth we ek post-treatment, respectively. It elicited a 100% efficacy in goats experimentally infected with F. hepatica metacercariae and treated at 18 weeks post-infection.