ACQUIRED FACTOR-VII DEFICIENCY ASSOCIATED WITH PLEURAL LIPOSARCOMA

Isolated acquired factor VII (FVII) deficiency (0.15 U/ml) was identif ied in a 30-year-old man with pleural liposarcoma. The patient underwe nt surgery with continuous FVII concentrate infusion. No anti-FVII ant ibody or FVII/anti-FVII complex was detected. However, the short half- life and low recovery of FVII after concentrate infusion suggested the presence of an antibody. Whatever the mechanism, this FVII deficiency was related to the presence of the liposarcoma. FVII level normalized during tumour regression and fell again when the liposarcoma relapsed .