INHIBITORS OF LIPID-PEROXIDATION AMONG NEW PYRIMIDO[1',6'1,2]PYRIDO[3,4-B]INDOLES

A series of potent inhibitors of NADPH- and Fe2+- dependant lipid pero xidation has been found among new pyrimido[1'6':1,2]pyrido[3,3-b]indol e derivatives. According to preliminary structure-activity relationshi p analysis the saturated pyrimidine moiety was responsible for this ef fect. Some members of this family were effective in a bilateral caroti d occlusion model in mice, and some derivatives showed protective effe ct in a mouse head injury model.