INHIBITORS OF LIPID-PEROXIDATION AMONG NEW PYRIMIDO[1',6'1,2]PYRIDO[3,4-B]INDOLES

Citation
Gy. Domany et al., INHIBITORS OF LIPID-PEROXIDATION AMONG NEW PYRIMIDO[1',6'1,2]PYRIDO[3,4-B]INDOLES, Die Pharmazie, 49(11), 1994, pp. 807-810
Citations number
40
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
00317144
Volume
49
Issue
11
Year of publication
1994
Pages
807 - 810
Database
ISI
SICI code
0031-7144(1994)49:11<807:IOLANP>2.0.ZU;2-U
Abstract
A series of potent inhibitors of NADPH- and Fe2+- dependant lipid pero xidation has been found among new pyrimido[1'6':1,2]pyrido[3,3-b]indol e derivatives. According to preliminary structure-activity relationshi p analysis the saturated pyrimidine moiety was responsible for this ef fect. Some members of this family were effective in a bilateral caroti d occlusion model in mice, and some derivatives showed protective effe ct in a mouse head injury model.