SYNTHESIS OF SOME NEW HETEROBICYCLIC COMPOUNDS CONTAINING SPIRO-1,2,4-TRIAZINE MOIETY AS POTENTIAL ANTI-HIV AND ANTICANCER AGENTS

Authors
ABDELRAHMAN RM SEADA M FAWZY M ELBAZ I
Citation
Rm. Abdelrahman et al., SYNTHESIS OF SOME NEW HETEROBICYCLIC COMPOUNDS CONTAINING SPIRO-1,2,4-TRIAZINE MOIETY AS POTENTIAL ANTI-HIV AND ANTICANCER AGENTS, Die Pharmazie, 49(11), 1994, pp. 811-814
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
49
Issue
11
Year of publication
1994
Pages
811 - 814
Database
ISI
SICI code
0031-7144(1994)49:11<811:SOSNHC>2.0.ZU;2-M
Abstract
A number of heterobicyclic compounds such as 1,3,5-thiazine, thiazolid inone, pyrimidine, pyrimidinedione, imidazole, quinazolinone and 1,2,4 -triazinone derivatives have been synthesized by reaction of ioxo-6-sp iro-(9'-fluorene)-1,2,4-triazin-5(4H)-one (1) with sulphur/nitrogen co mpounds in neutral or alkaline media. Structure elucidation of the new compounds have been carried out with the help of elemental analysis a nd spectral data. Some of these compounds were tested for in vitro ant i HIV and anticancer activities.