PHARMACOLOGICAL STUDIES ON NEW POTENTIAL LOCAL-ANESTHETICS

The results of the pharmacological screening of a series of new basic aminoalkyl aryl ethers are reported. The anesthetic effects of these c ompounds were evaluated by the guinea pig intradermal wheal test. Lido caine was used as the standard and normal saline as the control. These were, generally, better than or as good as the standard, in terms of potency, onset of action, duration of effect, time of full recovery fr om complete anesthesia and lack of both apparent local and systemic si de effects. The duration of action of their local anesthesia has shown a strong dependence on the substitution pattern of the compounds. Mor eover, it seems that these compounds act selectively and reversibly by blocking nervous conduction at a localized area, as small as a skin w heal, without any obvious deleterious untoward reactions, i.e. they ar e structurally specific and act at the neuronal channels (receptor sit es). Thus, due to their outstanding local anesthetic profiles, it is w orthy to conduct additional studies on these agents, as potential cand idates for the treatment of intolerable chronic pain, which does not r espond to mild analgesic drugs, and other available medicines.