Phospholipases, which modify phospholipids in natural membranes, are a
vailable from different sources for application in biocatalysis. All s
ites of phospholipids can be selectively modified by enzymatic catalys
is. By coupling the phospholipase action with well-established chemica
l transformations, natural and unnatural phospholipids can be prepared
. Phospholipids find application as pharmaceuticals, food additives, c
osmetics, in liposome technology and in gene transfer therapy.