PAF AND HEMATOPOIESIS .2. ELEVATED LEVELS OF PLASMA PAF ACETYLHYDROLASE AFTER RAPID INFUSION OF 5-FLUOROURACIL IN CANCER-PATIENTS

Authors
DENIZOT Y DUPUIS F ROULLET B PRALORAN V
Citation
Y. Denizot et al., PAF AND HEMATOPOIESIS .2. ELEVATED LEVELS OF PLASMA PAF ACETYLHYDROLASE AFTER RAPID INFUSION OF 5-FLUOROURACIL IN CANCER-PATIENTS, Cancer letters, 85(2), 1994, pp. 185-188
Citations number
15
Categorie Soggetti
Oncology
Journal title
Cancer letters → ACNP
ISSN journal
03043835
Volume
85
Issue
2
Year of publication
1994
Pages
185 - 188
Database
ISI
SICI code
0304-3835(1994)85:2<185:PAH.EL>2.0.ZU;2-G
Abstract
Blood platelet-activating factor (PAF) levels are regulated by a plasm a PAF acetylhydrolase. We investigated its levels in cancer patients d uring the course of a 5-day 5-fluorouracil (5-FU) treatment. PAF acety lhydrolase increased in nine patients with daily bolus infusion of 0.4 g 5-FU per m(2) of body surface (81.7 +/- 8.7 nmol PAF/min/ml vs. 66. 6 +/- 7.0; P < 0.001 for day 5 as compared to day 1). By contrast PAF acetylhydrolase did not change in seven patients with continuous infus ion of 5-FU. The meaning of these results is discussed in respect of t he immunoregulatory role of PAF.