Y. Denizot et al., PAF AND HEMATOPOIESIS .2. ELEVATED LEVELS OF PLASMA PAF ACETYLHYDROLASE AFTER RAPID INFUSION OF 5-FLUOROURACIL IN CANCER-PATIENTS, Cancer letters, 85(2), 1994, pp. 185-188
Blood platelet-activating factor (PAF) levels are regulated by a plasm
a PAF acetylhydrolase. We investigated its levels in cancer patients d
uring the course of a 5-day 5-fluorouracil (5-FU) treatment. PAF acety
lhydrolase increased in nine patients with daily bolus infusion of 0.4
g 5-FU per m(2) of body surface (81.7 +/- 8.7 nmol PAF/min/ml vs. 66.
6 +/- 7.0; P < 0.001 for day 5 as compared to day 1). By contrast PAF
acetylhydrolase did not change in seven patients with continuous infus
ion of 5-FU. The meaning of these results is discussed in respect of t
he immunoregulatory role of PAF.