CLOMIPHENE-EXPOSED PREGNANCIES, ANALYSIS OF 39 REQUESTS WITHIN 25 CASES OF KNOWN OUTCOMES

With the up to date published data, the risk of clomiphene exposure du ring pregnancy cannot be determined. After a review of animal experime ntation results, we will discuss the human data. Most of the publicati ons with human exposition concern treatments given before the beginnin g of pregnancy. The questions addressed to the Centre de Pharmacovigil ance of Paris F. Widal will be detailed. From May 1983 to July 1995 39 requests are available with only 25 cases of known outcomes. For thes e 25 cases, five elective terminations and three spontaneous abortions are reported. Only one defect was observed among the 17 births (9 fem ales, 8 males) : unilateral fibula agenesis the imputability of which is difficult to establish. These data seems reassuring; however, the n umber of patients studied is small. Other studies on clomiphene-expose d pregnancies are necessary in order to investigate this risk.