MINAPRINE TOXICITY EVALUATION BY THE FREN CH POISON CENTERS SINCE THETABLET DOSE CHANGE

By 1990, the Clin Midy (SANOFI) laboratory had modified the dose of Ca nter(R) tablets : the content of active drug (minaprine) increased (50 to 100 mg). Therefore, acute intoxication by minaprine can be serious , with generalized seizures, resisting the classic treatment. We tried to evaluate the possible consequence of this change of dose for the g ravity of suicide attempts. 1091 voluntary acute intoxications have be en collected by the national French Poisons Centres data bank, 226 of them py the Poisons center of Marseilles. We have compared, by the chi (2) method, the frequencies of seizure and death, before and after 199 0. Results are significant, confirming an increased gravity of these i ntoxications since the modification of dosage. Then, the laboratory re duced the number of tablets per box. We don't know if this measure wil l be efficient.