The diagnostic accuracy and complication rate of computer tomography (
CT)-guided small-caliber cutting needle biopsy were assessed in 103 bi
opsies in 101 consecutive patients. There were 67 true-positive, 30 tr
ue-negative, 3 false-negative and no false positive results. Two speci
mens were unclassifiable and one was insufficient. Diagnostic accuracy
was 94.1%, sensitivity 95.7%, and specificity 100%. In 34% of cases p
neumothorax occurred, requiring therapy in 24% of cases. The longer th
e intrapulmonary biopsy route was, the greater the risk of pneumothora
x. Except for transient hemoptysis in two patients, there were no furt
her complications. CT-guided small-caliber cutting needle biopsy of th
e lung is an effective and safe procedure, comparing well with fine ne
edle aspiration biopsy (FNAB). If exact histologic diagnosis is requir
ed it should be preferred to FNAB.