SELECTIVE TUBAL-STERILIZATION IN RABBITS - EXPERIENCE WITH A HYDROGELCOMBINED WITH A SCLEROSING AGENT

PURPOSE: To test a method of nonsurgical sterilization. MATERIALS AND METHODS: A hydrogel that forms an in situ plug by phase inversion of a polymer solution was placed into fallopian tubes of eight rabbits by means of transvaginal fluoroscopic fallopian tube catheterization. The rabbits were bred, and the presence of embryos was confirmed with pal pation and at autopsy. RESULTS: Seven of the eight rabbits became preg nant. Six of these rabbits contained embryos in the control uterus but not in the uterus on the side of the hydrogel injection. The seventh rabbit had embryos in both uteri, but the hydrogel had been expelled; All seven tubes that contained hydrogel Showed evidence of acute and c hronic salpingitis and a foreign-body reaction. The tube from which hy drogel had been expelled and the eight control tubes were not inflamed .CONCLUSION: Transcervical catheter methods of tubal occlusion and ste rilization are promising, but a nonreactive material is needed.