Two cases of an exophytic variant of fibrous dysplasia (fibrous dyspla
sia protuberans) are reported in which the lesions protruded far beyon
d the normal bone contour mimicking surface lesions of bone. The first
case was an 18-year-old man who had a pedunculated calcified mass of
the sixth rib in association with radiologically diagnosed fibrous dys
plasia of the skull. The second case was a 33-year-old man who had an
exophytic lesion of the proximal tibia. Both of these patients were sh
own to have benign fibro-osseous lesions consistent with fibrous dyspl
asia. The intramedullary portions of the host bone adjacent to the exo
phytic masses also were involved by the fibro-osseous lesions and this
fact suggests: that the lesions may arise eccentrically in the medull
ary spaces and mainly grow outwards. It is important to be aware that
fibrous dysplasia occasionally presents as an excrescence on the surfa
ce of bone. Careful radiographic and histological correlation is requi
red to make a correct diagnosis of this rare variant of fibrous dyspla
sia. (C) 1994 by W.B. Saunders Company