Ce. Whitworth et al., SPONTANEOUS DEVELOPMENT OF MALIGNANT PHASE HYPERTENSION IN TRANSGENICREN-2 RATS, Kidney international, 46(6), 1994, pp. 1528-1532
Spontaneous development of malignant phase hypertension in transgenic
Ren-2 rats. Spontaneous development of malignant phase hypertension in
TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mR
EN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to
human malignant phase hypertension are seen with an accelerated rise
in blood pressure, fibrinoid necrosis of renal afferent arterioles, re
nal failure and evidence of renin-angiotensin system activation. It ap
pears that introduction of an additional genetic factor or factors int
o a monogenic model of hypertension results in malignant phase hyperte
nsion.