SPONTANEOUS DEVELOPMENT OF MALIGNANT PHASE HYPERTENSION IN TRANSGENICREN-2 RATS

Spontaneous development of malignant phase hypertension in transgenic Ren-2 rats. Spontaneous development of malignant phase hypertension in TGR(mREN2)27 heterozygotes occurs as a consequence of crossing TGR(mR EN2)27 homozygotes with Edinburgh Sprague-Dawley rats. Similarities to human malignant phase hypertension are seen with an accelerated rise in blood pressure, fibrinoid necrosis of renal afferent arterioles, re nal failure and evidence of renin-angiotensin system activation. It ap pears that introduction of an additional genetic factor or factors int o a monogenic model of hypertension results in malignant phase hyperte nsion.