THE TOTAL SYNTHESIS OF A GLYCOSIDASE INHIBITOR, NAGSTATIN

Authors
TATSUTA K MIURA S GUNJI H
Citation
K. Tatsuta et al., THE TOTAL SYNTHESIS OF A GLYCOSIDASE INHIBITOR, NAGSTATIN, Bulletin of the Chemical Society of Japan, 70(2), 1997, pp. 427-436
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Bulletin of the Chemical Society of Japan → ACNP
ISSN journal
00092673
Volume
70
Issue
2
Year of publication
1997
Pages
427 - 436
Database
ISI
SICI code
0009-2673(1997)70:2<427:TTSOAG>2.0.ZU;2-0
Abstract
A glycosidase inhibitor, nagstatin, has been synthesized from protecte d L-ribofuranose through the inter- and intramolecular nucleophilic re actions of the imidazole moieties and the regioselective introduction of a carboxymethyl group.