Jo. Lewis et St. Crews, GENETIC-ANALYSIS OF THE DROSOPHILA SINGLE-MINDED GENE REVEALS A CENTRAL-NERVOUS-SYSTEM INFLUENCE ON MUSCLE DEVELOPMENT, Mechanisms of development, 48(2), 1994, pp. 81-91
The Drosophila single-minded gene is expressed in the embryonic centra
l nervous system midline cells and plays a critical role in central ne
rvous system development. Additional expression of single-minded is fo
und in a subset of ventral muscle precursor cells. Null mutations of s
ingle-minded result in an alteration of the ventral oblique muscles, s
uch that muscle fibers form inside the embryo above the central nervou
s system. This defect is due to the mislocalization of a subset of mes
odermal precursor cells. The muscle defect observed in single-minded n
ull mutations is not due to the absence of single-minded expression in
muscle precursor cells and likely results from an influence of the ce
ntral nervous system on ventral muscle development.