N-TERMINAL DOMAIN OF DYSTROPHIN

Contro-versial experiments have been published on calmodulin binding o f dystrophin. In this study, we used recombinant proteins and the tech niques of affinity chromatography and ELISA to show that the N-termina l part of dystrophin binds calmodulin specifically in a calcium-depend ent manner. The calcium-dependent interaction of calmodulin and dystro phin does not directly regulate binding of actin to dystrophin, but ma y regulate dystrophin interactions with other associated proteins.