CA2-ATPASE DISTRIBUTES DIFFERENTLY IN CARDIAC SARCOLEMMA THAN DIHYDROPYRIDINE RECEPTOR ALPHA-1 SUBUNIT AND NA+ CA2+ EXCHANGER()

Authors
IWATA Y HANADA H TAKAHASHI M SHIGEKAWA M
Citation
Y. Iwata et al., CA2-ATPASE DISTRIBUTES DIFFERENTLY IN CARDIAC SARCOLEMMA THAN DIHYDROPYRIDINE RECEPTOR ALPHA-1 SUBUNIT AND NA+ CA2+ EXCHANGER(), FEBS letters, 355(1), 1994, pp. 65-68
Citations number
18
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
355
Issue
1
Year of publication
1994
Pages
65 - 68
Database
ISI
SICI code
0014-5793(1994)355:1<65:CDDICS>2.0.ZU;2-B
Abstract
We have investigated the distribution of the sarcolemmal Ca2+ transpor ters in hamster and dog ventricular myocytes by immunocytochemical and membrane fractionation techniques. The data suggest that the DHP rece ptor alpha 1 subunit and the Na+/Ca2+ exchanger are present in surface sarcolemma as well as T-tubule membranes located at the cardiac dyads . Compared with these Ca2+ transporters, the sarcolemmal Ca2+-ATPase i s much less abundant in the latter fraction. Thus the sarcolemmal Ca2-ATPase seems to be located predominantly in surface sarcolemma.