A. Erenmemisoglu et al., NEUROMUSCULAR BLOCKING EFFECT OF THIAMPHENICOL ON FROG RECTUS-ABDOMINIS MUSCLE, General pharmacology, 25(7), 1994, pp. 1417-1420
1. In the present study, thiamphenicol caused a significant fall in AC
h-induced frog rectus abdominis muscle contraction peaks and significa
nt rightward shifts of the contractile response curves in a dose-depen
dent manner. 2. In addition, the maximal ACh response of muscle could
not be obtained in presence of thiamphenicol. On the other hand, thiam
phenicol did not alter KCl-induced contractions of the muscle at the s
ame concentrations. 3. In contrast chloramphenicol did not cause any s
ignificant change in ACh-induced contraction peaks. 4. These results h
ave suggested that thiamphenicol may have a neuromuscular blocking eff
ect on frog rectus abdominis muscle.