PROTECTION OF FERRETS AGAINST INFLUENZA CHALLENGE WITH A DNA VACCINE TO THE HEMAGGLUTININ

Authors
WEBSTER RG FYNAN EF SANTORO JC ROBINSON H
Citation
Rg. Webster et al., PROTECTION OF FERRETS AGAINST INFLUENZA CHALLENGE WITH A DNA VACCINE TO THE HEMAGGLUTININ, Vaccine, 12(16), 1994, pp. 1495-1498
Citations number
11
Categorie Soggetti
Immunology
Journal title
Vaccine → ACNP
ISSN journal
0264410X
Volume
12
Issue
16
Year of publication
1994
Pages
1495 - 1498
Database
ISI
SICI code
0264-410X(1994)12:16<1495:POFAIC>2.0.ZU;2-I
Abstract
Immunization of ferrets with a plasmid DNA expressing influenza virus haemagglutinin (pCMV/H1 DNA) provided complete protection from challen ge with the homologous A/PR/8/34 (H1N1) influenza virus. Delivery of D NA-coated gold beads by gene gun to the epidermis was much more effici ent than intramuscular delivery of DNA in aqueous solution. The antibo dy response induced by DNA delivered by gene gun was more cross-reacti ve than DNA delivered in aqueous solution or after natural infection. This novel approach to vaccination against influenza may afford broade r protection against antigenic drift than that provided by natural inf ection.