3-CYCLOPENTYL-1-ADAMANTANAMINES AND ADAMANTANEMETHANAMINES - ANTIVIRAL ACTIVITY EVALUATION AND CONVULSIONS STUDIES

Authors
FYTAS G MARAKOS P KOLOCOURIS N FOSCOLOS GB POULI N VAMVAKIDES A IKEDA S DECLERCQ E
Citation
G. Fytas et al., 3-CYCLOPENTYL-1-ADAMANTANAMINES AND ADAMANTANEMETHANAMINES - ANTIVIRAL ACTIVITY EVALUATION AND CONVULSIONS STUDIES, Il Farmaco, 49(10), 1994, pp. 641-647
Citations number
25
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
10
Year of publication
1994
Pages
641 - 647
Database
ISI
SICI code
0014-827X(1994)49:10<641:3AA-A>2.0.ZU;2-G
Abstract
The synthesis of 3-cyclopentyl-1-adamantanamines and adamantanemethana mines and some of their thioureas is described. The antiviral activity examination of these compounds indicated that some of them inhibited Respiratory Syncytial Virus (RSV) infection at concentrations that wer e slightly (up to 5-fold) lower than the cytotoxic concentration. Beha vioral and convulsions studies of the abovementioned amines, in mice, did not show any dopaminomimetic activity and argue in favor of the ex istence of a glutamatergic component in the action of these derivative s.