DISCRIMINATION OF SPERMIDINE AMINO FUNCTIONS BY A NEW PROTECTING GROUP STRATEGY APPLICATION TO THE SYNTHESIS OF GUANIDINYLATED POLYAMINES, INCLUDING HIRUDONINE

Authors
MITCHINSON A GOLDING BT GRIFFIN RJ OSULLIVAN MC
Citation
A. Mitchinson et al., DISCRIMINATION OF SPERMIDINE AMINO FUNCTIONS BY A NEW PROTECTING GROUP STRATEGY APPLICATION TO THE SYNTHESIS OF GUANIDINYLATED POLYAMINES, INCLUDING HIRUDONINE, Journal of the Chemical Society, Chemical Communications, (22), 1994, pp. 2613-2614
Citations number
25
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
22
Year of publication
1994
Pages
2613 - 2614
Database
ISI
SICI code
0022-4936(1994):22<2613:DOSAFB>2.0.ZU;2-C
Abstract
Agmatine and hirudonine, guanidine derivatives of putrescine and sperm idine, respectively, are synthesised by the application of a new prote cting group strategy for polyamines, which uses N-nitroguanidinyl as a precursor of guanidine functions and selectively blocks spermidine at N-1 and N-8 with trifluoroacetyl and at N-4 by 4-azidobenzyloxycarbon yl.