A NEW APPROACH TO RETINOIDS VIA ORGANOMETALLIC ADDITION TO PYRYLIUM-SALTS

Authors
HEMMING K DEMEDEIROS EF TAYLOR RJK
Citation
K. Hemming et al., A NEW APPROACH TO RETINOIDS VIA ORGANOMETALLIC ADDITION TO PYRYLIUM-SALTS, Journal of the Chemical Society, Chemical Communications, (22), 1994, pp. 2623-2624
Citations number
22
Categorie Soggetti
Chemistry
Journal title
Journal of the Chemical Society, Chemical Communications → ACNP
ISSN journal
00224936
Issue
22
Year of publication
1994
Pages
2623 - 2624
Database
ISI
SICI code
0022-4936(1994):22<2623:ANATRV>2.0.ZU;2-F
Abstract
A new, concise approach to retinoid synthesis is described based on or ganometallic addition to pyrylium salts; the use of 4-methylpyrylium t etrafluoroborate giving 13Z-retinal which is readily isomerised to ret inal itself; the corresponding unsubstituted and 4-cyclohexyl pyrylium salts are transformed into 13-H and 13-cyclohexyl retinal analogues.