Am. Wade et Ae. Ades, AGE-RELATED REFERENCE RANGES - SIGNIFICANCE TESTS FOR MODELS AND CONFIDENCE-INTERVALS FOR CENTILES, Statistics in medicine, 13(22), 1994, pp. 2359-2367
Citations number
24
Categorie Soggetti
Statistic & Probability","Medicine, Research & Experimental","Public, Environmental & Occupation Heath","Statistic & Probability
A method of fitting age-related reference ranges using maximized likel
ihood is presented. The method is illustrated using CD4. counts of uni
nfected children born to HIV-1 infected women. The likelihood incorpor
ates exponential functions to describe the Box-Cox transformation para
meter that induces Normality and the mean and standard deviation of th
e transformed data, at all ages in the range. This guarantees that the
centiles are asymptotic to notional adult values and avoids edge effe
cts. Likelihood ratio tests were used to assess the significance of th
e model parameters, and profile likelihood confidence intervals were c
onstructed around the fitted centiles. The asymptotes of the resulting
CD4 reference range for the childhood dataset were compared with CD4
counts available from a group of uninfected adults. The proposed appro
ach limits the need for arbitrary decisions about grouping of the data
, degree of smoothing or choice of model.