Organic, polymeric and biological samples form a class of materials wi
th increasing interest from both the fundamental and applicational poi
nts of view. Their characterization is a most challenging issue due to
their nature. As soft and fragile matters, they are subjected among o
thers, to radiation damage and deformation. in addition, they are gene
rally hydrated structures and so prone to denaturation under vacuum of
analysis chamber. Thus numerous possible artifacts can be induced in
the course of their characterization.