Extracorporeal photopheresis is a new therapeutic approach developed b
y Edelson et al.; it is conceptually designed for the management of di
seases mediated by malignant lymphocyte pathology, such as cutaneous T
-cell-lymphoma (CTCL), and other disorders mediated by aberrant lympho
cyte function, e.g. autoimmune diseases. The treatment is described in
this paper, and theories on the mechanisms of action are discussed. I
n addition, the indications for treatment with extracorporeal photophe
resis are discussed.