VALUE OF THE ANALYSIS OF NUCLEOLUS-ORGANI ZING REGIONS IN DERMATO-ONCOLOGY

Citation
A. Pfau et al., VALUE OF THE ANALYSIS OF NUCLEOLUS-ORGANI ZING REGIONS IN DERMATO-ONCOLOGY, Hautarzt, 45(11), 1994, pp. 762-768
Citations number
40
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
ISSN journal
00178470
Volume
45
Issue
11
Year of publication
1994
Pages
762 - 768
Database
ISI
SICI code
0017-8470(1994)45:11<762:VOTAON>2.0.ZU;2-D
Abstract
Nucleolus-organizing regions (AgNORs) are silver-stained loops of DNA transcribing to ribosomal RNA. Quantitative analysis helps to differen tiate normal tissue from malignant tissue and can be used for diagnosi s in several kinds of tumours. The analysis of AgNORs can also be used in dermatopathology for diagnostic and prognostic purposes. Apart fro m skin tumours such as basal,cell carcinomas and squamous cell carcino mas, this technique is of interest principally for melanocytic lesions . Benign naevi can be distinguished from malignant melanomas by simple counting of the AgNOR dots. For the differentiation of dysplastic nae vi, Spitz naevi and malignant melanomas, this parameter alone is not s ufficient. By combination of several AgNOR parameters (number, size, p attern of dispersal) only, significant differentiation could be achiev ed. The prognostic value of AgNORs remains to be examined.