DIPHTHERIA TOXIN-RELATED CYTOKINE FUSION PROTEINS - ELONGATION-FACTOR-2 AS A TARGET FOR THE TREATMENT OF NEOPLASTIC DISEASE

Authors
VANDERSPEK J COSENZA L WOODWORTH T NICHOLS JC MURPHY JR
Citation
J. Vanderspek et al., DIPHTHERIA TOXIN-RELATED CYTOKINE FUSION PROTEINS - ELONGATION-FACTOR-2 AS A TARGET FOR THE TREATMENT OF NEOPLASTIC DISEASE, Molecular and cellular biochemistry, 138(1-2), 1994, pp. 151-156
Citations number
36
Categorie Soggetti
Biology
Journal title
Molecular and cellular biochemistry → ACNP
ISSN journal
03008177
Volume
138
Issue
1-2
Year of publication
1994
Pages
151 - 156
Database
ISI
SICI code
0300-8177(1994)138:1-2<151:DTCFP->2.0.ZU;2-R
Abstract
We have used protein engineering and recombinant DNA methodologies in order to construct a fusion protein in which human interleukin-2 (IL-2 ) is genetically linked to the catalytic and transmembrane domains of diphtheria toxin. The fusion toxin, DAB(486) IL-2, is highly cytotoxic for only those cells which display the high affinity interleukin-2 re ceptor (IL-2R) on their surface. In phase I/II clinical studies the in travenous administration of DAB(486) IL-2 has been found to be safe, w ell tolerated and may lead to the induction of durable remissions in p atients presenting with a variety ofIL-2R positive lymphomas.