NAD GLYCOHYDROLASES - A POSSIBLE FUNCTION IN CALCIUM HOMEOSTASIS

Authors
KIM H JACOBSON EL JACOBSON MK
Citation
H. Kim et al., NAD GLYCOHYDROLASES - A POSSIBLE FUNCTION IN CALCIUM HOMEOSTASIS, Molecular and cellular biochemistry, 138(1-2), 1994, pp. 237-243
Citations number
45
Categorie Soggetti
Biology
Journal title
Molecular and cellular biochemistry → ACNP
ISSN journal
03008177
Volume
138
Issue
1-2
Year of publication
1994
Pages
237 - 243
Database
ISI
SICI code
0300-8177(1994)138:1-2<237:NG-APF>2.0.ZU;2-Z
Abstract
NAD glycohydrolases are the longest known enzymes that catalyze ADP-ri bose transfer. The function of these ubiquitous, membrane-bound enzyme s has been a long standing puzzle. The NAD glycohydrolases are briefly reviewed in light of the discovery by our laboratory that NAD glycohy drolases are bifunctional enzymes that can catalyze both the synthesis and hydrolysis of cyclic ADP-ribose, a putative second messenger of c alcium homeostasis.