IN-VITRO CYTOTOXICITY AGAINST HUMAN CANCER CELL-LINES DURING PULSED MAGNETIC-FIELD EXPOSURE

In an in vitro cell growth assay, carboplatin potency against A-431 ce lls increased after a 1 hour PMF (pulsed magnetic field) exposure (cal culated peak field 5.2 mTesla, with an average field strength of 0.525 mTesla(rms); pulses rose for 120 mu sec and then abruptly fell to neu tral and, were repeated at a rare of too ol 250 pulses per second). Th is potentiating effect was not observed with cisplatin or daunomycin. When cytotoxicity against HT-29 cells was measured, PMF exposure poten tiated both cal boplatin and daunomycin, but again, not cisplatin. Bot h cell types exhibited increased growth when exposed only to PMF. Expo sure to PMF consistently increased the cell growth of these cancer cel l lines, while only some in vitro antineoplastic agents were potentiat ed by PMFs.