IN-VITRO ACTIVITY OF TITANOCENEDICHLORIDE IN HUMAN RENAL-CELL CARCINOMA COMPARED TO CONVENTIONAL ANTINEOPLASTIC AGENTS

In the present study, the in vitro, activity of titanocenedichloride, a novel anticancer metal complex, in eleven primary renal cell carcino ma (RCC) specimens was evaluated by an adenosine triphosphate (ATP) bi oluminescence assay. Compared to standard antineoplastic agents such a s cisplatin, doxorubicin, mitoxantrone and vinblastine, titanocenedich loride was found to exhibit higher cytotoxicity. Four tumors showed st rong sensitivity to the new, agent Three of them were resistant to con ventional cytostatics. These findings indicated a lack of cross-resist ance between titanocenedichloride and both natural compounds as well a s platin analogues. Since mitoxantrone was also found to exhibit marke d antineoplastic activity with no evidence of cross-resistance to tita nocenedichloride, the combination of both drugs in RCC should be evalu ated further with additional in vitro studies.