J. Bergmann et al., MULTIPLE EFFECTS OF ANTITUMOR ALKYL-LYSOPHOSPHOLIPID ANALOGS ON THE CYTOSOLIC-FREE CA2-CANCER CELL-LINE( CONCENTRATION IN A NORMAL AND A BREAST), Anticancer research, 14(4A), 1994, pp. 1549-1556
Synthetic alkyl-lysophospholipids (ALP) are a new class of antitumor a
gents which interact with the cell membrane and the intracellular sign
al transduction at several sites. We studied the modulation of the int
racellular calcium concentration ([Ca++](i)) indllced by two alkylglyc
erophosphocholines as well as hexadecylphosphocholine and hexadecylpho
phoserine in a nontumorigenic and in a tumorigenic breast cell line. W
e found three distinct [Ca++](i)-modulating effects: a transient incre
ase, a decrease and a sustained increase. Their relative contribution
to the observed response varies with different cell types, with the pr
oliferation state, with the structure and with the concentration of th
e ALP analogs. The transient as well as the sustained increase in [Ca+](i) depend mainly on extracellular Ca++; however, the Ca++ influx-in
ducing pathways might be different. The multiple [Ca++](i)-increasing
and decreasing effects induced by ALP analogs are discussed in relatio
n to their influence on numerous Ca++-dependent effects, e.g. prolifer
ation differentiation, apoptosis and cytotoxicity.