SYNTHESIS AND ENANTIOSELECTIVE HYDROGENATION OF ALPHA-ACYLOXYACRYLATES

Authors
SCHMIDT U LANGNER J KIRSCHBAUM B BRAUN C
Citation
U. Schmidt et al., SYNTHESIS AND ENANTIOSELECTIVE HYDROGENATION OF ALPHA-ACYLOXYACRYLATES, Synthesis, (11), 1994, pp. 1138-1140
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthesis → ACNP
ISSN journal
00397881
Issue
11
Year of publication
1994
Pages
1138 - 1140
Database
ISI
SICI code
0039-7881(1994):11<1138:SAEHOA>2.0.ZU;2-O
Abstract
Numerous alpha-acyloxyacrylates have been prepared by Wittig-Horner re action of aldehydes and ethyl 2-acyloxy-2-(diethoxyphosphoryl)acetates which were easily obtained from glyoxylic acid hydrate. The formed al pha-acyloxyacrylates were subsequently hydrogenated enantioselectively using Rh-DIPAMP and Ru-BINAP (ee = 82-98%) to furnish the correspondi ng alpha-acyloxycarboxylates.