COAMPLIFICATION IN HUMAN BREAST-TUMORS AND PHYSICAL LINKAGE AT CHROMOSOMAL BAND 12P13, OF CCND2 AND FGF6 GENES

Authors
DIB A ADELAIDE J COURJAL F COURSEAUX A JACQUEMIER J GAUDRAY P THEILLET C PEBUSQUE MJ BIRNBAUM D
Citation
A. Dib et al., COAMPLIFICATION IN HUMAN BREAST-TUMORS AND PHYSICAL LINKAGE AT CHROMOSOMAL BAND 12P13, OF CCND2 AND FGF6 GENES, International journal of oncology, 5(6), 1994, pp. 1375-1378
Citations number
24
Categorie Soggetti
Oncology
Journal title
International journal of oncology → ACNP
ISSN journal
10196439
Volume
5
Issue
6
Year of publication
1994
Pages
1375 - 1378
Database
ISI
SICI code
1019-6439(1994)5:6<1375:CIHBAP>2.0.ZU;2-A
Abstract
The CCND2 and FGF6 genes are both located at band p13 of human chromos ome 12. The two genes are coamplified in some cases (3.6%) of breast t umors. They are physically linked within a 500 kb genomic segment. Thu s, both 11q13 and 12p13 chromosomal regions host related linked cyclin and FGF genes, and can be amplified in human tumors. This strengthens the hypothesis of genome duplication involving chromosomes 11 and 12.