CHEMOENZYMATIC SYNTHESIS OF OPTICALLY PURE 1,3,4-OXADIAZOL-2(3H)-ONESWITH ACARICIDAL ACTIVITY

Authors
BOSETTI A BIANCHI D LAPORTA P BETTARINI F MASSIMINI S
Citation
A. Bosetti et al., CHEMOENZYMATIC SYNTHESIS OF OPTICALLY PURE 1,3,4-OXADIAZOL-2(3H)-ONESWITH ACARICIDAL ACTIVITY, Journal of agricultural and food chemistry, 42(11), 1994, pp. 2596-2599
Citations number
13
Categorie Soggetti
Food Science & Tenology",Agriculture,"Chemistry Applied
Journal title
Journal of agricultural and food chemistry → ACNP
ISSN journal
00218561
Volume
42
Issue
11
Year of publication
1994
Pages
2596 - 2599
Database
ISI
SICI code
0021-8561(1994)42:11<2596:CSOOP1>2.0.ZU;2-C
Abstract
Both enantiomers of ethyl-3-(2-chlorophenyl)-1,3,4-oxadiazol-2(3H)-one (1a), a new compound with high ovicidal activity against Tetranychus urticae (Koch), were synthesized starting from enzymatically prepared optically pure 2-[4-(isopropoxy)phenyl]propanoic acid (3). Laboratory tests have shown that the biological activity of the R isomer is at le ast 400-fold higher than that of the S form.