PHOSPHATIDYLETHANOL FORMATION AND DEGRADATION IN BRAINS OF ACUTELY AND REPEATEDLY ETHANOL-TREATED RATS

Authors
LUNDQVIST C ARADOTTIR S ALLING C BOYANOADANEZ MD GUSTAVSSON L
Citation
C. Lundqvist et al., PHOSPHATIDYLETHANOL FORMATION AND DEGRADATION IN BRAINS OF ACUTELY AND REPEATEDLY ETHANOL-TREATED RATS, Neuroscience letters, 179(1-2), 1994, pp. 127-131
Citations number
22
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
179
Issue
1-2
Year of publication
1994
Pages
127 - 131
Database
ISI
SICI code
0304-3940(1994)179:1-2<127:PFADIB>2.0.ZU;2-R
Abstract
The formation of the abnormal phospholipid phosphatidylethanol (PEth) was studied in hippocampus, cerebellum and cerebrum of rat brain after intraperitoneal ethanol administration. Prior to analysis by high per formance thin layer chromatography PEth was purified. After one inject ion, PEth levels reached a maximum after 2 h and remained detectable f or 14-24 h in all three regions. Repeated injections led to additional accumulation. Maximum in vivo levels of 30-50 nmol/g wet wt. were rea ched.