PERSISTENTLY ENHANCED RATIO OF NMDA AND NON-NMDA COMPONENTS OF RAT HIPPOCAMPAL EPSC AFTER BLOCK OF A(1) ADENOSINE RECEPTORS AT INCREASED [CA2+](O) [MG2+](O)

Authors
KLISHIN A LOZOVAYA N KRISHTAL O
Citation
A. Klishin et al., PERSISTENTLY ENHANCED RATIO OF NMDA AND NON-NMDA COMPONENTS OF RAT HIPPOCAMPAL EPSC AFTER BLOCK OF A(1) ADENOSINE RECEPTORS AT INCREASED [CA2+](O) [MG2+](O), Neuroscience letters, 179(1-2), 1994, pp. 132-136
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
179
Issue
1-2
Year of publication
1994
Pages
132 - 136
Database
ISI
SICI code
0304-3940(1994)179:1-2<132:PERONA>2.0.ZU;2-H
Abstract
NMDA and non-NMDA receptor-mediated components of excitatory post-syna ptic current (EPSC) were studied by in situ whole-cell voltage-clamp r ecordings in the CA1 field of rat hippocampus. We found that the ampli tudes ratio of the NMDA to the non-NMDA components can be strongly inc reased by blocking A(1) adenosine receptors. The necessary conditions for this effect are both, increased Ca2+ and lowered Mg2+ in the exter nal medium. The so achieved increase in the NMDA/non-NMDA ratio of EPS C components is irreversible and no longer depends on the activity of A(1) adenosine receptors.