REGULATION OF DIACYLGLYCEROL KINASE IN RAT-BRAIN MEMBRANES BY DOCOSAHEXAENOIC ACID

Authors
VAIDYANATHAN VV RAO KVR SASTRY PS
Citation
Vv. Vaidyanathan et al., REGULATION OF DIACYLGLYCEROL KINASE IN RAT-BRAIN MEMBRANES BY DOCOSAHEXAENOIC ACID, Neuroscience letters, 179(1-2), 1994, pp. 171-174
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Neuroscience letters → ACNP
ISSN journal
03043940
Volume
179
Issue
1-2
Year of publication
1994
Pages
171 - 174
Database
ISI
SICI code
0304-3940(1994)179:1-2<171:RODKIR>2.0.ZU;2-S
Abstract
The effect of docosahexaenoic acid (DHA) on the diacylglycerol kinase (DG kinase) activity in rat brain membranes was investigated. DHA at 5 00 mu M concentration, stimulated the enzyme activity by about 2 fold. This effect was concentration-and time-dependent and was observed aft er very short periods of incubation (one min). DHA stimulation of DG k inase was observed only with rat brain membranes, and not with rat bra in cytosol or rat liver membranes. Treating the rat brain membranes wi th phospholipase A(2) which released free fatty acids including DHA, s ignificantly stimulated the DG kinase activity. It is concluded that D HA through its stimulatory effect on DG kinase may regulate the signal ling events in growth-related situations in the brain such as synaptog enesis.