ION-SELECTIVE MEMBRANE-ELECTRODE FOR IMIP RAMINE - CONSTRUCTION, ELECTROANALYTICAL CHARACTERIZATION AND PHARMACEUTICAL APPLICATION

The paper presents the construction and the performance characteristic s of a new membrane electrode selective to imipramine cation drug. The construction is based on the used of the ion-pair association of imip ramine hydrochloride and dinonylnaphthalenesulphonic acid embedded in a PVC matrix. The electrode exhibits a near-Nernstian response in the range 10(-2) - 10(-5) mol 1(-1) and a low detection limit of about 5x1 0(-6) mol 1(-1). It was studied its selectivity over a series of the p otentially interfering species. The electrode response was independent of pH in the range 2.5-5.0. The electrode can be used successfully fo r the determination of imipramine hydrochloride in pharmaceuticals wit hout any prior separation, with an average error of less than 1.00%.