FOLLICLE CYST FORMATION AFTER ADMINISTRATION OF DIFFERENT GONADOTROPIN-RELEASING-HORMONE ANALOGS FOR ASSISTED REPRODUCTION

The aim of this study was to examine the occurrence of ovarian cysts d uring the administration of three different gonadotrophin-releasing ho rmone analogues (GnRHa) in the long protocol as well as their characte ristics, management and outcome compared with patients with no cyst fo rmation. A total of 172 in-vitro fertilization (IVF) cycles in which G nRHa was administered at menstruation were analysed. Group B consisted of 72 cycles in which buserelin was used. Of these, 10 (13.9%) were w ith cysts (group B1) and 62 (86.1%) without cysts (group B2). Group T included 49 cycles in which triptorelin was injected. Of these, seven (14.2%) were with cysts (group T1) and 42 (85.7%) without cysts (group T2). Group L comprised 51 cycles in which leuprolide was administered . Of these, eight (15.7%) were with cysts (group L1) and 43 (84.3%) wi thout cysts (group L2). All women,vith ovarian cysts had higher serum oestradiol concentrations and all except five underwent cyst aspiratio n with no complication. No differences were observed in the number of follicles and oocytes between groups B, T and L or between the groups with cysts and those without cysts. The pregnancy rate was similar in all groups. In conclusion, follicle cyst formation does not seem to be related to the use of a specific GnRHa, its short- or long-acting for m or to the mode of administration. In addition, follicle cyst aspirat ion is a safe and successful solution to the problem of functionally a ctive ovarian cysts.