GENETICS OF CROHNS-DISEASE - NO LINK WITH THE PSEUDOAUTOSOMAL REGION OF THE X-CHROMOSOME

Objective: In view of the high prevalence of Crohn's disease among wom en with Turner's syndrome, we searched for a putative Crohn's disease locus on the X chromosome, which is deleted in Turner's syndrome. Subj ects and methods: Because Crohn's disease is equally prevalent in men and women, the search was focused on the pseudoautosomal region of the X chromosome. Blood samples from two families with healthy siblings a nd siblings with Crohn's disease were analysed by restriction fragment length polymorphism. The probes used in the analysis were derived fro m the pseudoautosomal region of the X chromosome. Results: No link was found between Crohn's disease and the pseudoautosomal region of the X chromosome. Conclusion: The putative Crohn's disease locus is not loc ated in the pseudoautosomal region of the X chromosome.