ABSORPTION OF ORGANIC-ANIONS AS MODEL-DRUGS FOLLOWING APPLICATION TO RAT-LIVER SURFACE IN-VIVO

Absorption of organic anions (phenol red, bromphenol blue and bromosul phonphthalein) has been studied after their application to rat liver s urface in-vivo, employing a cylindrical glass cell (i.d. 9 mm, area 0. 64 cm(2)). Each drug appeared gradually in the blood with the peak lev el at about 1 h, after which its concentration declined slowly. Absorb ed model drug was efficiently excreted into the bile. These observatio ns appear to indicate the possibility of drug absorption from liver su rface membrane. Absorption of model drugs was estimated to be more tha n 59% in 6h. The biliary recovery and metabolism of phenol red did not change as compared with that after intravenous administration.