Hx. Zhou, CONTROL OF REDUCTION POTENTIAL BY PROTEIN MATRIX - LESSON FROM A SPHERICAL PROTEIN MODEL, JBIC. Journal of biological inorganic chemistry, 2(1), 1997, pp. 109-113
Factors that contribute to the control of reduction potential by prote
in matrix are examined within a spherical protein model. These include
the nonpolar nature of protein matrices, solvent accessibility of the
redox center, and net charges and dipoles of surrounding amino acids.
Simple rules on their effects are established. In particular, surface
charges have little effect on the reduction potential, and polar grou
ps may either increase or decrease the reduction potential, depending
on their orientations relative to the redox center, The effects of com
plex formation, proton titration, and ionic strength are also discusse
d.