C. Lejossic et al., EXPRESSION OF HELIX-LOOP-HELIX FACTOR ID-1 IS DEPENDENT ON THE HEPATOCYTE PROLIFERATION AND DIFFERENTIATION STATUS IN RAT-LIVER AND IN PRIMARY CULTURE, Cancer research, 54(23), 1994, pp. 6065-6068
Id proteins are known as negative regulators of differentiation in var
ious cell types. In this report, we show that the Id-1 gene was downre
gulated during the development of rat liver. No Id-1 transcripts were
detected in terminal differentiated hepatocytes. We have studied Id-1
expression in proliferating hepatocytes using an in vivo model of live
r regeneration after partial hepatectomy and an in vitro growth factor
-stimulated hepatocyte culture system. Strong activation of Id-1 was o
bserved in mid-late G(1) of the hepatocyte cell cycle at a time corres
ponding to a mitogen restriction point. These observations suggest tha
t Id-1 is involved in the control of proliferation and differentiation
in liver cells.