ENANTIOMERICALLY ENRICHED ALPHA-VINYL AMINO-ACIDS VIA LIPASE-MEDIATEDREVERSE TRANSESTERIFICATION

Authors
BERKOWITZ DB PUMPHREY JA SHEN QR
Citation
Db. Berkowitz et al., ENANTIOMERICALLY ENRICHED ALPHA-VINYL AMINO-ACIDS VIA LIPASE-MEDIATEDREVERSE TRANSESTERIFICATION, Tetrahedron letters, 35(47), 1994, pp. 8743-8746
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
47
Year of publication
1994
Pages
8743 - 8746
Database
ISI
SICI code
0040-4039(1994)35:47<8743:EEAAVL>2.0.ZU;2-1
Abstract
Reduction of protected alpha-vinyl amino acids produces ''neopentyl'' alcohols that may be enriched in the L-antipode by lipase-mediated acy lation with vinyl acetate. Subsequent deacetylation, oxidation and hyd rolysis yields enantiomerically enriched L-alpha-vinyl amino acids.