CALOPOROSIDE, A NEW INHIBITOR OF PHOSPHOLIPASES C FROM CALOPORUS-DICHROUS (FR) RYV

Authors
WEBER W SCHU P ANKE T VELTEN R STEGLICH W
Citation
W. Weber et al., CALOPOROSIDE, A NEW INHIBITOR OF PHOSPHOLIPASES C FROM CALOPORUS-DICHROUS (FR) RYV, Journal of antibiotics, 47(11), 1994, pp. 1188-1194
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
11
Year of publication
1994
Pages
1188 - 1194
Database
ISI
SICI code
0021-8820(1994)47:11<1188:CANIOP>2.0.ZU;2-R
Abstract
A new salicylic acid derivative, caloporoside, was isolated from ferme ntations of Caloporus dichrous. Its structure was elucidated by a comb ination of chemical and spectroscopic methods. Caloporoside exhibits w eak antibacterial and antifungal activities and is a quite selective i nhibitor of phospholipase C isolated from pig brain (Ki 12, 3 mu M).