ALDECALMYCIN, A NEW ANTIMICROBIAL ANTIBIOTIC FROM STREPTOMYCES .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

Authors
SAWA R TAKAHASHI Y ITOH S SHIMANAKA K KINOSHITA N HOMMA Y HAMADA M SAWA T NAGANAWA H TAKEUCHI T
Citation
R. Sawa et al., ALDECALMYCIN, A NEW ANTIMICROBIAL ANTIBIOTIC FROM STREPTOMYCES .1. TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES, Journal of antibiotics, 47(11), 1994, pp. 1266-1272
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Immunology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
47
Issue
11
Year of publication
1994
Pages
1266 - 1272
Database
ISI
SICI code
0021-8820(1994)47:11<1266:AANAAF>2.0.ZU;2-U
Abstract
A new antibiotic, aldecalmycin, has been discovered in the culture bro th of Streptomyces sp. MJ147-72F6. Aldecalmycin was purified by solven t extraction, Diaion HP-20 chromatography, silica gel chromatography, Sephadex LH-20 chromatography, HPLC and centrifugal partition chromato graphy. The H-1 and C-13 NMR spectra of aldecalmycin showed the presen ce of keto-enol tautomers. Aldecalmycin is equipotent in inhibiting th e growth of sensitive and methicillin-resistant Staphylococcus aureus (MRSA).