NEW NEMATOCIDAL AND ANTIMICROBIAL COMPOUNDS FROM THE BASIDIOMYCETE CHEIMONOPHYLLUM-CANDIDISSIMUM (BERK AND CURT) SING .1. PRODUCING ORGANISM, FERMENTATION, ISOLATION, AND BIOLOGICAL-ACTIVITIES

Six new bisabolane type sesquiterpenoids, cheimonophyllons A (1), B (2 ), C (3), D (4), E (5), and cheimonophyllal (6) were isolated from the culture fluid of the basidiomycete, Cheimonophyllum candidissimum. Th e compounds exhibited nematicidal, weak antifungal and antibacterial a s well as cytotoxic activities. The main product, cheimonophyllon A (1 ) (C15H22O4), was also active in the Ames mutagenicity test.