In this prospective study, we compared the histological results of Pip
elle endometrial sampling (PES) with that of hysterectomy to examine w
hether endometrial sampling with the Pipelle device can accurately dia
gnose endometrial carcinoma. PES was performed in 26 patients with kno
wn endometrial carcinoma whose initial therapy consisted of hysterecto
my. Discomfort and pain during the biopsy were reported to be mild by
22 patients, moderate by 3 patients and severe by only 1 patient. All
of the samples were found to be adequate. Twenty-four of 26 PES confir
med endometrial carcinoma, a correlation of 95%, and the histological
grade reported on PES agreed with that of hysterectomy specimens in 87
.5% of the patients. On the other hand, the tumor grade in the specime
ns obtained at dilation and curettage correlated with hysterectomy spe
cimens in 95% of the patients. We conclude that Pipelle is an accurate
device in patients with endometrial carcinoma.