SYNTHESIS AND REACTIONS OF 3-AMINO-2-METHYL-4(3H)-QUINAZOLINONE DERIVATIVES

Authors
YASSIN FA EISSA AMF WASFY AAF
Citation
Fa. Yassin et al., SYNTHESIS AND REACTIONS OF 3-AMINO-2-METHYL-4(3H)-QUINAZOLINONE DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 33(12), 1994, pp. 1193-1196
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
33
Issue
12
Year of publication
1994
Pages
1193 - 1196
Database
ISI
SICI code
0376-4699(1994)33:12<1193:SARO3D>2.0.ZU;2-7
Abstract
3-Amino-2-methyl-4(3H)-quinazolinone (2) has been synthesized by treat ing 2-methylbenzoxazinone (1) with hydrazine hydrate. Reaction of quin azolinone (2) with phenyl isothiocyanate and phenyl isocyanate furnish the corresponding aminocarbothiamide and aminocarbamide derivatives ( 3 and 5), respectively, which on reaction with malonic acid in acetyl chloride afford thiobarbituric and barbituric acid derivatives (4 and 6), respectively. Behaviour of compound 5 towards different aldehydes, ketones and imides have been investigated.