A FACILE HALOGEN EXCHANGE OF ACTIVE METHYLENE CHLORO COMPOUNDS

Authors
BHALERAO UT RAJU BC NEELAKANTAN P
Citation
Ut. Bhalerao et al., A FACILE HALOGEN EXCHANGE OF ACTIVE METHYLENE CHLORO COMPOUNDS, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 33(12), 1994, pp. 1197-1199
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
33
Issue
12
Year of publication
1994
Pages
1197 - 1199
Database
ISI
SICI code
0376-4699(1994)33:12<1197:AFHEOA>2.0.ZU;2-Y
Abstract
An unexpected exchange of chlorine with bromine occurs during benzylat ion of 2-chloro-4'-hydroxy-3', 5'-dimethylacetophenone (1a) with benzy l bromide. The products (2, 3 and 4) formed constitute a 60:40 mixture of chloro and bromo derivatives. A simple methodology for such an exc hange in two-phase system with aq. HBr in the presence of phase transf er catalyst (PTC) is described.